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Preparative Chromatography for Separation of Proteins (Wiley Series in Biotechnology and Bioengineering), by Arne Staby, Anurag S. Rathore
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Preparative Chromatography for Separation of Proteins addresses a wide range of modeling, techniques, strategies, and case studies of industrial separation of proteins and peptides.
•�� �Covers broad aspects of preparative chromatography with a unique combination of academic and industrial perspectives
•��� Presents Combines modeling with compliantce useing of Quality-by-Design (QbD) approaches including modeling
•�� �Features a variety of chromatographic case studies not readily accessible to the general public
•�� �Represents an essential reference resource for academic, industrial, and pharmaceutical researchers
- Sales Rank: #9051014 in Books
- Published on: 2017-02-28
- Original language: English
- Number of items: 1
- Dimensions: .0" h x .0" w x .0" l, .0 pounds
- Binding: Hardcover
- 592 pages
From the Back Cover
Using preparative chromatography to separate protein and peptides is a key tool for biopharmaceutical purification. Although theory and models have been available for many years, industrial usage of these tools has been scarce. However, recently implemented Quality by Design (QbD) concepts have lead to greater application of modeling in commercial process development and manufacture of protein and peptide separations systems.
Written for those biotechnologists, biochemists, pharmaceutical scientists, and bioengineers working on this aspect of drug development; Preparative Chromatography for Separation of Proteins addresses a wide range of modeling techniques, strategies, and case studies of industrial separation of proteins and peptides.
The chapters in the first section cover basic modeling and reviews, with focus on chromatographic theory developments and research on the fundamentals of chromatographic separation and protein behavior. Chapters in the second section relate to industrial separations, addressing trends in chromatographic unit operations and how mechanistic and empirical modeling approaches help optimize equipment and methodologies, as well as industrial case histories of various modeling approaches — like multivariate data analysis, DoE, and mechanistic modeling for design space, on-column refolding etc.
With its unique pairing of academic and industrial perspectives, Preparative Chromatography for Separation of Proteins is an indispensable resource for all those involved in the purification of biopharmaceuticals.
About the Author
Arne Staby is a Fellow and Senior Principal Scientist at Novo Nordisk A/S and the author of numerous papers and presentations in the field.
Anurag S. Rathore is a Professor in the Department of Chemical Engineering at the Indian Institute of Technology, Delhi, India. He has published several books that include Quality by Design for Biopharmaceuticals: Principles and Case Studies (Wiley, 2009).
Satinder Ahuja is President of Ahuja Consulting and the author/editor of numerous books including Chiral Separation Methods for Pharmaceutical and Biotechnological Products; Trace and Ultratrace Analysis by HPLC; and Selectivity and Detectability Optimizations in HPLC – all published by Wiley.Most helpful customer reviews
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